Abnormal sleep physiology in children with dup15q syndrome

August 3, 2021

Abnormal sleep physiology in children with 15q11.2-13.1 duplication (Dup15q) syndrome

This study has shown that children with Dup15q syndrome have abnormal sleep rhythms and these sleep physiological changes may contribute to or worsen cognitive and neurodevelopmental abilities in our children. Considering the role of GABAergic neurotransmission in the generation of beta oscillations and in healthy NREM sleep physiology, the EEG signatures we see here, together, likely reflect aberrant GABAergic neurotransmission and help establish mechanisms that may underlie the abnormal physiology in this condition.