Cumulative Impact of Polychlorinated Biphenyl and Large Chromosomal Duplications on DNA Methylation, Chromatin, and Expression of Autism Candidate Genes.
The Dup15q postmortem brain exhibited global DNA hypomethylation over synaptic genes
The Dup15q cell model revealed cumulative effects of duplications and PCB 95 exposure
Increased UBE3A in Dup15q reduced RING1, affecting transcription of synaptic genes
Known druggable autism genes were enriched in cumulative genetic and PCB 95 lists