Hypotonia in dup15q syndrome contributes to gross motor delays, and/or gastrointestinal issues such as constipation. Gastrointestinal issues throughout development are reported in dup15q syndrome. GI symptoms were present in 76.7% of individuals with idic15 duplication and 87.5% with an interstitial duplication. Behaviors such as irritability and aggressiveness improved with the treatment of GI symptoms in several subjects.
A Gastrointestinal Exam is recommended for any of the following symptoms:
- feeding issues, “failure to thrive”
- difficulty swallowing
- gastroesophageal reflux
- encopresis (stool with-holding)
- “foamy” stools, etc.
Past Conference Presentation On GI ISSUES In dup15q syndrome:
Mark Corkins, M.D., C.N.S.C., F.A.A.P., Division Chief of Pediatric Gastroenterology, Le Bonheur Children’s Hospital, Professor of Pediatrics, University of Tennessee Health Science Center