Summary: Properties of beta oscillations in Dup15q syndrome

January 14, 2021
Properties of beta oscillations in Dup15q syndrome

(Summary by JoAnne Mosel, Joe Elassal,  edited Vidya Saravanapandian)

By Vidya Saravanapandian, Joel Frohlich, Joerg F. Hipp, Carly Hyde, Aaron W. Scheffler, Peyman Golshani, Edwin H. Cook, Lawrence T. Reiter, Damla Senturk and Shafali S. Jeste. 

A previous study, “Mechanisms underlying the EEG biomarker in Dup15q syndrome” confirmed the presence of beta waves on EEGs of children with dup15q and determined “GABAA receptor” genes play a role in these unique beta brain waves. This signature EEG pattern could help scientists develop animal models to better understand dup15q and to aid in clinical trials of drugs that target these GABA receptors and potentially help treat symptoms including seizures in our kids.

This study represents a follow-up to the study mentioned above and looked at a larger number of children with dup15q to further delve into understanding the potential for using this EEG signature (excessive beta oscillations) as a biomarker in Dup15q. 

We can use as an endpoint this unique beta wave signature as a measure to reflect effective drug target engagement. For example, a drug that targets GABA receptors could potentially reduce the amount of