Autism protein may shape neuronal firing patterns

January 14, 2021

Autism protein may shape neuronal firing patterns

Published on Spectrum News 1/14/21 BY ANGIE VOYLES ASKHAM

Excess UBE3A, an autism-linked protein, may shape how neurons fire, according to unpublished research presented virtually on Monday at the 2021 Society for Neuroscience Global Connectome.  (Links to abstracts may work only for registered conference attendees.)The findings may offer an explanation for some of the traits seen in people with dup15q syndrome, which is caused by the duplication of a stretch of chromosome 15 where the UBE3A gene resides.Most people with this syndrome have some form of autism, and many have epilepsyintellectual disability and developmental delay. But how UBE3A protein affects de