Consistent, convergent pathways link two forms of autism

November 15, 2022

Consistent, convergent pathways link two forms of autism

BY ANGIE VOYLES ASKHAM  /  15 NOVEMBER 2022 / https://doi.org/10.53053/OWUW9177

The brains of people with a duplication of the 15q11-13 chromosomal region have dysregulated gene expression, particularly in excitatory upper-layer neurons of the cerebral cortex, according to an unpublished study presented yesterday at Neuroscience 2022 in San Diego, California.

This duplication is one of the most common genetic causes of autism. People with dup15q syndrome and those with idiopathic autism, in which the genetic cause is unknown, show some similar patterns of altered gene expression in upper-layer neurons,